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By Target- ADC Cytotoxin
- Drug-Linker Conjugates for ADC(1)
- Microtubule Associated(1)
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Results for "
SPP DM1
" in TargetMol Product Catalog- Inhibitors & Agonists2
- PROTAC Products2
SPP-DM1
T18718452072-20-7
SPP-DM1, a drug-linker conjugate for antibody-drug conjugates (ADC), demonstrates potent antitumor activity. It comprises DM1 (a potent microtubule-disrupting agent) connected through the ADC linker SPP[1].
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Mertansine
Cited
T1992139504-50-0
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine.
- $30
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